1 00:00:00,600 --> 00:00:09,370 [Music] 2 00:00:15,500 --> 00:00:11,420 we're gonna do a little bit about her 3 00:00:17,480 --> 00:00:15,510 nieces recognizing the hormesis is a 4 00:00:19,960 --> 00:00:17,490 stimulatory effect of a low dose of the 5 00:00:22,490 --> 00:00:19,970 substance that is toxic at a higher dose 6 00:00:25,300 --> 00:00:22,500 just sounds a little bit contradictory 7 00:00:27,710 --> 00:00:25,310 but we'll see that it is contradictory 8 00:00:30,140 --> 00:00:27,720 oftentimes the hormetic effect is 9 00:00:33,100 --> 00:00:30,150 described as giving a u-shaped or J 10 00:00:36,410 --> 00:00:33,110 shaped curve where if you look at the 11 00:00:41,440 --> 00:00:36,420 these couple graphs will see that at low 12 00:00:43,790 --> 00:00:41,450 dose a particular molecule might give a 13 00:00:45,920 --> 00:00:43,800 stimulatory effect and a higher dose an 14 00:00:48,229 --> 00:00:45,930 inhibitory or if we look at the opposite 15 00:00:49,970 --> 00:00:48,239 side we see a low dose decrease as 16 00:00:54,709 --> 00:00:49,980 negative effects a high dose induces the 17 00:00:57,470 --> 00:00:54,719 negative effects back in 1972 an 18 00:01:00,619 --> 00:00:57,480 allergist in Mobile Alabama wrote a 19 00:01:03,560 --> 00:01:00,629 paper in the journal of medicine for 20 00:01:06,350 --> 00:01:03,570 Alabama reporting a very rapid relief of 21 00:01:10,370 --> 00:01:06,360 flu symptoms by using the flu vaccine 22 00:01:13,550 --> 00:01:10,380 itself in a sub vaccine dose he did this 23 00:01:16,430 --> 00:01:13,560 by intradermal injection of the of the 24 00:01:18,350 --> 00:01:16,440 flu vaccine and reported a decrease in 25 00:01:21,730 --> 00:01:18,360 symptoms within five to six minutes 26 00:01:24,280 --> 00:01:21,740 after the introduction of the vaccine in 27 00:01:27,679 --> 00:01:24,290 1979 he published another little paper 28 00:01:30,200 --> 00:01:27,689 saying that the same sort of sub vaccine 29 00:01:32,240 --> 00:01:30,210 dose of the flu vaccine also worked on 30 00:01:36,980 --> 00:01:32,250 herpes infections with people that had 31 00:01:40,760 --> 00:01:36,990 act of violence in his reports dr. 32 00:01:43,340 --> 00:01:40,770 Miller noted a couple things one is he 33 00:01:45,289 --> 00:01:43,350 was insistent on using the current 34 00:01:48,280 --> 00:01:45,299 year's vaccine for treating the current 35 00:01:50,780 --> 00:01:48,290 year's disease where their flu or herpes 36 00:01:53,510 --> 00:01:50,790 however is a bit of a contradiction to 37 00:01:55,850 --> 00:01:53,520 that he had the impression that some 38 00:01:58,039 --> 00:01:55,860 vaccines some years vaccines were a 39 00:01:59,780 --> 00:01:58,049 little more potent than others so he 40 00:02:01,670 --> 00:01:59,790 would keep those in reserve in case he 41 00:02:05,380 --> 00:02:01,680 had a recalcitrant patient that didn't 42 00:02:12,500 --> 00:02:08,930 also of interest is that he reported no 43 00:02:14,720 --> 00:02:12,510 success in using this flu vaccine for 44 00:02:19,580 --> 00:02:14,730 treating any kind and the other kind of 45 00:02:21,440 --> 00:02:19,590 viral infection so two years later dr. 46 00:02:22,910 --> 00:02:21,450 Miller invited me to come down and see 47 00:02:24,560 --> 00:02:22,920 his practice for if 48 00:02:26,540 --> 00:02:24,570 interview some of the patients reviewers 49 00:02:28,700 --> 00:02:26,550 data make some procedure or observe his 50 00:02:32,170 --> 00:02:28,710 procedures and I came away with a few 51 00:02:35,150 --> 00:02:32,180 questions that he wasn't able to answer 52 00:02:37,370 --> 00:02:35,160 first one the obvious one and making the 53 00:02:38,900 --> 00:02:37,380 assumption which is by the way valid his 54 00:02:41,090 --> 00:02:38,910 observations were valid that he was 55 00:02:43,630 --> 00:02:41,100 seeing these rapid responses in these 56 00:02:47,540 --> 00:02:43,640 patients with hurt with herpes or flu 57 00:02:50,930 --> 00:02:47,550 infections why only those two families 58 00:02:52,730 --> 00:02:50,940 of virus has responded and what's the 59 00:02:55,580 --> 00:02:52,740 common denominator between those two 60 00:02:57,710 --> 00:02:55,590 they are quite unlike one another in the 61 00:03:00,890 --> 00:02:57,720 sense that herpes viruses are 62 00:03:03,260 --> 00:03:00,900 double-stranded DNA the influenza 63 00:03:06,350 --> 00:03:03,270 viruses are single-stranded RNA of 64 00:03:07,910 --> 00:03:06,360 course the the influenza is pretty much 65 00:03:10,520 --> 00:03:07,920 restricted to the respiratory tract 66 00:03:12,020 --> 00:03:10,530 herpes goes here there and everywhere so 67 00:03:15,050 --> 00:03:12,030 what kind of common denominator do we 68 00:03:17,600 --> 00:03:15,060 have and what in the vaccine is doing 69 00:03:25,280 --> 00:03:17,610 the work that was really the fundamental 70 00:03:29,750 --> 00:03:25,290 question for me the kind of a sub-theme 71 00:03:31,760 --> 00:03:29,760 was why why is he insistent on this 72 00:03:34,220 --> 00:03:31,770 year-to-year difference in the potency 73 00:03:36,830 --> 00:03:34,230 of respective of the respective 74 00:03:38,540 --> 00:03:36,840 influenza vaccines we went back to our 75 00:03:40,610 --> 00:03:38,550 labs in New York and in Providence Rhode 76 00:03:43,490 --> 00:03:40,620 Island did some collaborative work with 77 00:03:45,350 --> 00:03:43,500 people at the City of Hope and what we 78 00:03:48,200 --> 00:03:45,360 did was tear apart the viruses that are 79 00:03:52,760 --> 00:03:48,210 in the flu vaccine we looked at the RNA 80 00:03:55,130 --> 00:03:52,770 core the various Koch proteins we looked 81 00:03:56,750 --> 00:03:55,140 at the hmm you'll remember that h1n1 82 00:03:58,640 --> 00:03:56,760 just ants for hemagglutinin and 83 00:04:00,890 --> 00:03:58,650 neuraminidase that's the H and the N and 84 00:04:04,040 --> 00:04:00,900 different years vaccines have different 85 00:04:06,080 --> 00:04:04,050 ages and ends and we looked at these 86 00:04:08,420 --> 00:04:06,090 various components of the viruses that 87 00:04:11,870 --> 00:04:08,430 were in the vaccines and found that 88 00:04:15,260 --> 00:04:11,880 really when we evaluated them both in 89 00:04:17,990 --> 00:04:15,270 vivo and in vitro nothing happened that 90 00:04:22,190 --> 00:04:18,000 they didn't do anything at all so that 91 00:04:25,880 --> 00:04:22,200 brings us back to the question of why 92 00:04:30,320 --> 00:04:25,890 would one year's flu vaccine work on 93 00:04:31,969 --> 00:04:30,330 another year's cases you'll recall that 94 00:04:34,610 --> 00:04:31,979 dr. Miller kept some of their really hot 95 00:04:36,090 --> 00:04:34,620 stuff for recalcitrant credit cases and 96 00:04:38,730 --> 00:04:36,100 yet we know that he 97 00:04:41,090 --> 00:04:38,740 flu vaccine is different than every 98 00:04:43,770 --> 00:04:41,100 other years in anticipation of whatever 99 00:04:47,250 --> 00:04:43,780 strain of Luis not to be going to cause 100 00:04:50,880 --> 00:04:47,260 the problem that year what's common to 101 00:04:54,960 --> 00:04:50,890 each year's vaccine the preservative is 102 00:04:56,940 --> 00:04:54,970 the answer it had nothing to do with the 103 00:04:59,130 --> 00:04:56,950 act what we thought was the active agent 104 00:05:03,270 --> 00:04:59,140 it was instead of the preservative which 105 00:05:05,190 --> 00:05:03,280 is by Marisol now hi Marisol you know 106 00:05:08,010 --> 00:05:05,200 has a bit of a clouded history recently 107 00:05:10,140 --> 00:05:08,020 if that's the formula for it there and 108 00:05:12,360 --> 00:05:10,150 you can see in each G in there that's a 109 00:05:14,880 --> 00:05:12,370 mercury containing preservative it was 110 00:05:17,220 --> 00:05:14,890 used in vaccines for years and years we 111 00:05:19,950 --> 00:05:17,230 just abbreviate t ml because it's easier 112 00:05:22,560 --> 00:05:19,960 to say it's a very well studied toxin 113 00:05:24,680 --> 00:05:22,570 it's a potent antimicrobial and 114 00:05:27,870 --> 00:05:24,690 antifungal agent we know it's used 115 00:05:31,020 --> 00:05:27,880 mercurochrome or thiolate and it's a 116 00:05:33,270 --> 00:05:31,030 classic example in our hands of hormesis 117 00:05:36,150 --> 00:05:33,280 or in hormesis exhibiting molecule 118 00:05:38,310 --> 00:05:36,160 because in low doses we see a very 119 00:05:43,010 --> 00:05:38,320 positive response with respect to some 120 00:05:46,800 --> 00:05:45,090 it's not hard to figure out what the 121 00:05:49,110 --> 00:05:46,810 concentration of thimerosal is in the 122 00:05:52,170 --> 00:05:49,120 vaccines it's about 50 milligrams per 123 00:05:55,770 --> 00:05:52,180 dose we found a universal dose of time 124 00:05:58,560 --> 00:05:55,780 aerosol to be about 250 times less 125 00:06:01,080 --> 00:05:58,570 concentrated the key here other than 126 00:06:04,110 --> 00:06:01,090 concentration is that term Universal 127 00:06:07,710 --> 00:06:04,120 dose because this is a classic Universal 128 00:06:10,320 --> 00:06:07,720 dose what that means is the dose is 129 00:06:12,600 --> 00:06:10,330 constant for every patient regardless of 130 00:06:15,210 --> 00:06:12,610 mass of the patient the patient's age 131 00:06:19,500 --> 00:06:15,220 their gender the degree of affliction 132 00:06:22,200 --> 00:06:19,510 and even what species they are here's an 133 00:06:25,950 --> 00:06:22,210 idea of where we used a universal dose 134 00:06:28,170 --> 00:06:25,960 in all of these the first one the cows 135 00:06:31,070 --> 00:06:28,180 get herpes infections malignant 136 00:06:33,930 --> 00:06:31,080 catarrhal fever is a almost universal 137 00:06:37,110 --> 00:06:33,940 universally fatal disease in cattle 138 00:06:38,910 --> 00:06:37,120 that's transmitted from sheep to cows we 139 00:06:40,710 --> 00:06:38,920 did the work here at Colorado State at 140 00:06:42,900 --> 00:06:40,720 the veterinary school there and showed 141 00:06:44,790 --> 00:06:42,910 that we could reverse that disease 142 00:06:46,469 --> 00:06:44,800 Nia mellitus another infection of Kyle's 143 00:06:48,600 --> 00:06:46,479 run down through these real quickly but 144 00:06:50,100 --> 00:06:48,610 the point is whether cheek wine herpes 145 00:06:52,230 --> 00:06:50,110 or the carrot 146 00:06:54,059 --> 00:06:52,240 Titus and cats which is an eye infection 147 00:06:56,070 --> 00:06:54,069 rabbit pox looks like it ought to be a 148 00:06:58,800 --> 00:06:56,080 pox virus but it's really our herpes and 149 00:07:00,029 --> 00:06:58,810 all these human herpes infections 150 00:07:02,580 --> 00:07:00,039 simplex one and two 151 00:07:05,490 --> 00:07:02,590 Epstein bar virus is a causative agent 152 00:07:06,689 --> 00:07:05,500 for infectious mononucleosis and some 153 00:07:08,300 --> 00:07:06,699 people report that it might be 154 00:07:11,219 --> 00:07:08,310 associated with some kinds of cancers 155 00:07:15,390 --> 00:07:11,229 again going back to dr. Bauer's 156 00:07:17,159 --> 00:07:15,400 presentation CMV cytomegalovirus there 157 00:07:18,330 --> 00:07:17,169 are more and more epidemiological 158 00:07:20,879 --> 00:07:18,340 information to show that that's a 159 00:07:23,219 --> 00:07:20,889 causative agent for hypertension and for 160 00:07:25,800 --> 00:07:23,229 some cardiovascular diseases and about 161 00:07:28,409 --> 00:07:25,810 98 percent of this population our US 162 00:07:31,279 --> 00:07:28,419 population has that virus herpes zoster 163 00:07:33,809 --> 00:07:31,289 causes chicken pox and shingles and 164 00:07:36,300 --> 00:07:33,819 herpes also is responsible for many 165 00:07:39,209 --> 00:07:36,310 cases of Bell's palsy the point of this 166 00:07:42,180 --> 00:07:39,219 slide is that the same dose is used 167 00:07:45,330 --> 00:07:42,190 whether it's on a 2,000 pound cow a six 168 00:07:48,330 --> 00:07:45,340 pound cat or a 150 pound human it's the 169 00:07:50,850 --> 00:07:48,340 same dose same response time same effect 170 00:07:53,100 --> 00:07:50,860 and it's also true for all the 171 00:07:55,769 --> 00:07:53,110 influences but only interestingly enough 172 00:07:58,709 --> 00:07:55,779 for the true flus the true flu they're 173 00:08:01,680 --> 00:07:58,719 called influenza A and B these are the 174 00:08:05,670 --> 00:08:01,690 ones that give the nasty flu symptoms 175 00:08:06,689 --> 00:08:05,680 the muscle weakness the lethargy the 176 00:08:11,279 --> 00:08:06,699 stuff that's going to knock you out for 177 00:08:13,800 --> 00:08:11,289 seven to ten days in the para flus which 178 00:08:16,589 --> 00:08:13,810 are the 24-hour flus the thimerosal has 179 00:08:20,700 --> 00:08:16,599 no effect at all so that's kind of an 180 00:08:23,070 --> 00:08:20,710 interesting twist to things also so we 181 00:08:27,180 --> 00:08:23,080 wanted to know what's happening how is 182 00:08:29,579 --> 00:08:27,190 the tml working and we've done some some 183 00:08:32,939 --> 00:08:29,589 genetics or genomics work in our own lab 184 00:08:34,350 --> 00:08:32,949 and we found and I know nobody wants to 185 00:08:35,939 --> 00:08:34,360 keep track of these different genes but 186 00:08:37,829 --> 00:08:35,949 just to let you know that we have 187 00:08:42,659 --> 00:08:37,839 Albrecht up regulation of some genes 188 00:08:47,250 --> 00:08:42,669 like the eye f-16c cl5 these are potent 189 00:08:49,680 --> 00:08:47,260 anti-inflammatory or related genes we 190 00:08:52,740 --> 00:08:49,690 have down-regulation of interleukins 1b 191 00:08:56,490 --> 00:08:52,750 and 6 to medicos factor alpha interferon 192 00:08:58,319 --> 00:08:56,500 gamma those are pro-inflammatory so if 193 00:09:00,180 --> 00:08:58,329 they're down regulated there's less of 194 00:09:03,010 --> 00:09:00,190 an inflammatory response and 195 00:09:05,410 --> 00:09:03,020 interestingly enough when we deliver 196 00:09:08,080 --> 00:09:05,420 just I'm aerosol in the universal dose 197 00:09:10,300 --> 00:09:08,090 to a person that has a mouthful for 198 00:09:13,270 --> 00:09:10,310 example of herpes lesions within a 199 00:09:15,520 --> 00:09:13,280 matter of minutes that pain is gone it 200 00:09:16,510 --> 00:09:15,530 goes just that quickly this is because 201 00:09:18,400 --> 00:09:16,520 of the up regulation of the 202 00:09:20,950 --> 00:09:18,410 anti-inflammatory is the down regulation 203 00:09:23,470 --> 00:09:20,960 of the pro-inflammatory this polar to 204 00:09:25,660 --> 00:09:23,480 aging is especially important in 205 00:09:28,000 --> 00:09:25,670 determining mechanism of action because 206 00:09:31,090 --> 00:09:28,010 it's responsible in part for reading the 207 00:09:33,340 --> 00:09:31,100 genetic code of the infecting virus so 208 00:09:34,930 --> 00:09:33,350 if that's down regulated the virus 209 00:09:38,170 --> 00:09:34,940 cannot replicate with the degree of 210 00:09:40,900 --> 00:09:38,180 efficiency it might have before as a 211 00:09:43,210 --> 00:09:40,910 consequence of that what we see is an 212 00:09:46,060 --> 00:09:43,220 inability of an infectious agent to 213 00:09:49,900 --> 00:09:46,070 replicate that is to say even in the 214 00:09:52,960 --> 00:09:49,910 face of tml therapy the virus can get in 215 00:09:56,290 --> 00:09:52,970 into the susceptible cell it becomes 216 00:09:58,330 --> 00:09:56,300 uncoated new virus components can be 217 00:10:00,280 --> 00:09:58,340 made but they can't be reassembled so 218 00:10:03,010 --> 00:10:00,290 that's the end of infection and again 219 00:10:07,840 --> 00:10:03,020 this happens extremely quickly just as 220 00:10:09,870 --> 00:10:07,850 an example or two with EBV EBV the 221 00:10:12,940 --> 00:10:09,880 epstein-barr virus and mononucleosis 222 00:10:14,080 --> 00:10:12,950 it's not uncommon for college students 223 00:10:16,210 --> 00:10:14,090 for example especially if they're 224 00:10:18,370 --> 00:10:16,220 college athletes to lose a semester of 225 00:10:21,400 --> 00:10:18,380 athletic activity because of infectious 226 00:10:23,020 --> 00:10:21,410 mono if we see a patient with mono start 227 00:10:25,390 --> 00:10:23,030 to treat them they might lose one or 228 00:10:26,730 --> 00:10:25,400 even two practices and that's it they're 229 00:10:31,780 --> 00:10:26,740 back in operation 230 00:10:34,600 --> 00:10:31,790 likewise with a herpes infection for 231 00:10:39,220 --> 00:10:34,610 example of some women will get a herpes 232 00:10:40,990 --> 00:10:39,230 on the lip that will predate the onset 233 00:10:42,820 --> 00:10:41,000 of the menstrual cycle and they'll know 234 00:10:44,260 --> 00:10:42,830 that two or three days before the 235 00:10:46,750 --> 00:10:44,270 menstrual cycle begins there's going to 236 00:10:49,690 --> 00:10:46,760 be this lesion on the lip if that woman 237 00:10:51,250 --> 00:10:49,700 takes a drop of the universal dose of 238 00:10:54,520 --> 00:10:51,260 Simon aerosol under her tongue 239 00:10:56,740 --> 00:10:54,530 sublingual dose every 15 minutes for an 240 00:10:58,990 --> 00:10:56,750 hour usually by the second drop there'll 241 00:11:00,430 --> 00:10:59,000 be no tingling or numbness sensation 242 00:11:01,930 --> 00:11:00,440 that she would have in her lip the 243 00:11:03,610 --> 00:11:01,940 lesion will never develop and that's the 244 00:11:07,150 --> 00:11:03,620 end of that so this is a really 245 00:11:08,560 --> 00:11:07,160 remarkable way to control the disease so 246 00:11:11,530 --> 00:11:08,570 what are we going to do about it 247 00:11:13,450 --> 00:11:11,540 well again getting back to dr. Bauer's 248 00:11:15,670 --> 00:11:13,460 presentation we're going to do clinical 249 00:11:16,450 --> 00:11:15,680 trials and in fact we're in the process 250 00:11:18,220 --> 00:11:16,460 of that 251 00:11:20,400 --> 00:11:18,230 we have what's called an open IND for 252 00:11:24,550 --> 00:11:20,410 influenza there was timed exactly 253 00:11:27,220 --> 00:11:24,560 terribly we had permission from the FDA 254 00:11:29,020 --> 00:11:27,230 to do a trial right at the time of the 255 00:11:31,170 --> 00:11:29,030 the last big scale it's a swine flu or 256 00:11:33,580 --> 00:11:31,180 the bird flu couple or three seasons ago 257 00:11:35,920 --> 00:11:33,590 just as that was winding down we got 258 00:11:37,870 --> 00:11:35,930 permission to gear up and since then 259 00:11:39,250 --> 00:11:37,880 there hasn't been any flu to speak of so 260 00:11:44,290 --> 00:11:39,260 that just sits on the shelf doing 261 00:11:45,940 --> 00:11:44,300 nothing in opposition to that we also 262 00:11:48,240 --> 00:11:45,950 have permission from the FDA to do 263 00:11:51,400 --> 00:11:48,250 what's called a phase two study with 264 00:11:54,430 --> 00:11:51,410 patients who suffer herpes infections 265 00:11:57,580 --> 00:11:54,440 following a dental procedure that is an 266 00:12:00,220 --> 00:11:57,590 ongoing trial we have patients in the 267 00:12:01,990 --> 00:12:00,230 world several sites upstate New York and 268 00:12:03,430 --> 00:12:02,000 a private practice then we have three 269 00:12:05,830 --> 00:12:03,440 dental schools involved at Buffalo 270 00:12:07,630 --> 00:12:05,840 Kentucky and Pittsburgh that trial is 271 00:12:10,990 --> 00:12:07,640 anticipated to be finished this summer 272 00:12:13,480 --> 00:12:11,000 and it's a blinded trial so we don't 273 00:12:14,680 --> 00:12:13,490 know the results but from anecdotal work 274 00:12:18,370 --> 00:12:14,690 with hundreds and hundreds of patients 275 00:12:21,820 --> 00:12:18,380 over the years we expect a positive 276 00:12:25,060 --> 00:12:21,830 result so conclusion stall this are 277 00:12:27,130 --> 00:12:25,070 these sigh Marisol is certainly in our 278 00:12:28,240 --> 00:12:27,140 hands and in the hands of physicians and 279 00:12:31,510 --> 00:12:28,250 veterinarians we've worked with for 280 00:12:34,270 --> 00:12:31,520 years a very potent inhibitor of both 281 00:12:36,280 --> 00:12:34,280 influenzas true influenzas and all the 282 00:12:39,760 --> 00:12:36,290 herpes viruses all of them without 283 00:12:41,560 --> 00:12:39,770 exception it's safe again at these 284 00:12:43,240 --> 00:12:41,570 concentrations recognizing that in 285 00:12:46,270 --> 00:12:43,250 higher concentrations it's anything but 286 00:12:49,450 --> 00:12:46,280 safe it's incredibly inexpensive it's 287 00:12:51,100 --> 00:12:49,460 easily administered just another hint 288 00:12:52,810 --> 00:12:51,110 we've talked about sublingual 289 00:12:54,820 --> 00:12:52,820 administration in humans just a drop 290 00:12:57,700 --> 00:12:54,830 under the tongue we do that also with 291 00:13:00,130 --> 00:12:57,710 dogs and cats owners seem to like that 292 00:13:03,400 --> 00:13:00,140 for the larger animals like cows and 293 00:13:05,500 --> 00:13:03,410 horses the same dose is given by sub-q 294 00:13:08,320 --> 00:13:05,510 ejection get the same results in the 295 00:13:11,500 --> 00:13:08,330 same amount of time so we look at 296 00:13:14,170 --> 00:13:11,510 America tml as a classic example of 297 00:13:17,200 --> 00:13:14,180 hormesis where a toxin at high 298 00:13:19,350 --> 00:13:17,210 concentrations given it the proper low 299 00:13:22,710 --> 00:13:19,360 concentration can be a very useful 300 00:13:25,260 --> 00:13:22,720 therapeutic agent that's it 301 00:13:31,850 --> 00:13:25,270 thank you 302 00:13:36,450 --> 00:13:34,800 yes John I'd like to ask you you talked 303 00:13:39,840 --> 00:13:36,460 about the dosages and different animals 304 00:13:43,680 --> 00:13:39,850 of different yes okay yes Karl med would 305 00:13:47,280 --> 00:13:43,690 have so I questioned you John is have 306 00:13:49,410 --> 00:13:47,290 you tried dosages based on mass for a 307 00:13:51,840 --> 00:13:49,420 different animals so changing the dose 308 00:13:53,700 --> 00:13:51,850 by mass and what they're what if any 309 00:13:55,710 --> 00:13:53,710 difference was there in response 310 00:13:57,240 --> 00:13:55,720 well we yes we have done that and we see 311 00:13:58,650 --> 00:13:57,250 the exact thing I mentioned on the 312 00:14:02,430 --> 00:13:58,660 u-shape bridgetta curve 313 00:14:04,440 --> 00:14:02,440 higher dose we get we can get a negative 314 00:14:06,930 --> 00:14:04,450 effect or no effect lower dose also a 315 00:14:09,590 --> 00:14:06,940 negative effect so mass just plain has 316 00:14:12,720 --> 00:14:09,600 nothing to do with it 317 00:14:19,020 --> 00:14:12,730 hi John my name's Emery Mort thank you 318 00:14:20,820 --> 00:14:19,030 for your presentation my question is in 319 00:14:23,970 --> 00:14:20,830 terms of a mechanistic understanding of 320 00:14:25,890 --> 00:14:23,980 why a low dose works the same on 321 00:14:28,770 --> 00:14:25,900 different sized mammals have you 322 00:14:33,140 --> 00:14:28,780 considered Rupert Sheldrake's morphic 323 00:14:36,090 --> 00:14:33,150 field theory and that perhaps the 324 00:14:39,510 --> 00:14:36,100 medicine is hitting like a trigger unit 325 00:14:40,680 --> 00:14:39,520 that sets off a cascade of okay you're 326 00:14:44,340 --> 00:14:40,690 shaking your head so that's exactly 327 00:14:46,080 --> 00:14:44,350 what's happening okay the administer the 328 00:14:48,030 --> 00:14:46,090 medicine is simply acting as a signal 329 00:14:50,040 --> 00:14:48,040 and that's why interestingly enough you 330 00:14:52,140 --> 00:14:50,050 can get the same response with the same 331 00:14:55,050 --> 00:14:52,150 dose given sublingually or 332 00:14:56,940 --> 00:14:55,060 subcutaneously so once the trigger is 333 00:14:59,310 --> 00:14:56,950 pooled that cascade occurs that results 334 00:15:02,400 --> 00:14:59,320 in the desired outcome but that's that's 335 00:15:04,290 --> 00:15:02,410 all it's doing thank you and my second 336 00:15:06,480 --> 00:15:04,300 question is have you observed or 337 00:15:13,710 --> 00:15:06,490 researched a decline effect in the 338 00:15:20,680 --> 00:15:18,160 hi York Dobyns and I'd like to ask 339 00:15:24,520 --> 00:15:20,690 whether that the description you just 340 00:15:27,370 --> 00:15:24,530 gave of hormesis is perhaps getting 341 00:15:30,910 --> 00:15:27,380 things a little bit turned around since 342 00:15:32,940 --> 00:15:30,920 it as far as I know almost anything is 343 00:15:35,830 --> 00:15:32,950 toxic in sufficiently large 344 00:15:38,830 --> 00:15:35,840 concentrations so it doesn't seem to be 345 00:15:41,170 --> 00:15:38,840 any surprise that a lot of toxins are 346 00:15:47,230 --> 00:15:41,180 harmless or even beneficial in very low 347 00:15:50,620 --> 00:15:47,240 doses I have no argument or anything 348 00:15:53,650 --> 00:15:50,630 about that the point of the matter is is 349 00:15:55,780 --> 00:15:53,660 that what might have been avoided 350 00:15:59,110 --> 00:15:55,790 because of toxic consequences can be 351 00:16:01,060 --> 00:15:59,120 utilized as a as a decent therapeutic 352 00:16:03,160 --> 00:16:01,070 agent in these low doses that's the only 353 00:16:05,010 --> 00:16:03,170 point I think from a practical 354 00:16:06,640 --> 00:16:05,020 standpoint and some really nice 355 00:16:08,740 --> 00:16:06,650 epidemiological work that's been coming 356 00:16:10,750 --> 00:16:08,750 out in the last few years shows that we 357 00:16:12,660 --> 00:16:10,760 all know for example that radiation has 358 00:16:15,870 --> 00:16:12,670 some pretty serious adverse effects 359 00:16:19,090 --> 00:16:15,880 there have been enough people retiring 360 00:16:22,270 --> 00:16:19,100 from careers in the radiation industry 361 00:16:23,920 --> 00:16:22,280 now as a result of simple aging as you 362 00:16:26,680 --> 00:16:23,930 might think that those people that have 363 00:16:28,000 --> 00:16:26,690 been exposed to relatively small amounts 364 00:16:29,500 --> 00:16:28,010 of radiation day in and day out for 365 00:16:30,760 --> 00:16:29,510 years would have higher incidence of 366 00:16:32,860 --> 00:16:30,770 certain kinds of cancer and especially 367 00:16:35,170 --> 00:16:32,870 leukemias and just the opposite is true 368 00:16:36,670 --> 00:16:35,180 the epidemiological evidence now shows 369 00:16:38,920 --> 00:16:36,680 that those people actually have a lower 370 00:16:42,430 --> 00:16:38,930 incidence than Joe and Mary on the 371 00:16:44,470 --> 00:16:42,440 street so the fact that what you're 372 00:16:47,830 --> 00:16:44,480 saying is not terribly revolutionary 373 00:16:53,050 --> 00:16:47,840 other than for making it useful that's 374 00:16:54,370 --> 00:16:53,060 that's the only point Bob Patterson I'm 375 00:16:56,410 --> 00:16:54,380 sort of curious how are you gonna make 376 00:16:58,600 --> 00:16:56,420 money on this I assume it might not be 377 00:17:00,120 --> 00:16:58,610 proprietary and after other discussions 378 00:17:04,740 --> 00:17:00,130 how is you as a commercial enterprise 379 00:17:09,820 --> 00:17:04,750 gonna be making profit it is proprietary 380 00:17:11,410 --> 00:17:09,830 and it is patented and the we will be 381 00:17:12,850 --> 00:17:11,420 the mercenaries like other people and 382 00:17:14,020 --> 00:17:12,860 license it out to the big pharma company 383 00:17:18,280 --> 00:17:14,030 so they can rape the public and me 384 00:17:20,290 --> 00:17:18,290 everybody makes money good morning 385 00:17:21,189 --> 00:17:20,300 what's the motive excretion on all the 386 00:17:25,840 --> 00:17:21,199 different animals 387 00:17:26,889 --> 00:17:25,850 mercury some has breathed off other goes 388 00:17:30,070 --> 00:17:26,899 out through the feces this is 389 00:17:34,299 --> 00:17:30,080 ethylmercury not not methyl so it's a 390 00:17:38,080 --> 00:17:34,309 less toxic incent and in fact we have 391 00:17:41,110 --> 00:17:38,090 patients both who have mostly human that 392 00:17:43,299 --> 00:17:41,120 have been on the the sublingual drops of 393 00:17:45,909 --> 00:17:43,309 this substance for years without 394 00:17:49,389 --> 00:17:45,919 interruption and we can't find anything 395 00:17:51,580 --> 00:17:49,399 in the way of toxicity hi Christine Hart 396 00:17:53,850 --> 00:17:51,590 any effect on post herpetic neuralgia 397 00:17:56,110 --> 00:17:53,860 you bet 398 00:17:57,580 --> 00:17:56,120 yes we combined it with one other 399 00:18:06,330 --> 00:17:57,590 molecule and we can pretty well take 400 00:18:12,110 --> 00:18:09,180 hi John I'm Kenny Arnett I'm wondering 401 00:18:15,810 --> 00:18:12,120 first of all what your take on the 402 00:18:18,210 --> 00:18:15,820 debate over autism and thimerosal is and 403 00:18:22,140 --> 00:18:18,220 secondly what's the relationship between 404 00:18:23,460 --> 00:18:22,150 your work and homeopathy okay the first 405 00:18:25,140 --> 00:18:23,470 of all with respect to autism we do 406 00:18:27,810 --> 00:18:25,150 we've done quite a bit of work with that 407 00:18:30,539 --> 00:18:27,820 disease ourselves you know familiar with 408 00:18:31,649 --> 00:18:30,549 the epidemiology or that's been done in 409 00:18:35,880 --> 00:18:31,659 the last three or four years that 410 00:18:38,159 --> 00:18:35,890 strongly suggest that mercury or at 411 00:18:40,649 --> 00:18:38,169 least say Marysol is not a causative 412 00:18:43,200 --> 00:18:40,659 agent of autism that doesn't mean it's 413 00:18:46,320 --> 00:18:43,210 not in the minds of a lot of people but 414 00:18:49,620 --> 00:18:46,330 what we have found is this opt ism is 415 00:18:51,960 --> 00:18:49,630 certainly a multifactorial disease just 416 00:18:54,120 --> 00:18:51,970 to give you an example you know we have 417 00:18:57,930 --> 00:18:54,130 one family in Sacramento who had a three 418 00:18:59,970 --> 00:18:57,940 or three or four year old daughter who 419 00:19:02,340 --> 00:18:59,980 developed autism about two weeks after 420 00:19:04,350 --> 00:19:02,350 being vaccinated and so you know they 421 00:19:06,659 --> 00:19:04,360 the antennae go up and there's a problem 422 00:19:08,490 --> 00:19:06,669 and that child has become frankly 423 00:19:12,180 --> 00:19:08,500 autistic institutionalized and so forth 424 00:19:14,580 --> 00:19:12,190 they had a younger son of who because of 425 00:19:16,110 --> 00:19:14,590 the parents knowledge and aggressiveness 426 00:19:18,299 --> 00:19:16,120 and learning about autism decided not to 427 00:19:20,460 --> 00:19:18,309 vaccinate the boy when he got to be 428 00:19:24,659 --> 00:19:20,470 three years old he became autistic also 429 00:19:26,760 --> 00:19:24,669 without any vaccine so that's that's one 430 00:19:28,289 --> 00:19:26,770 part of it I think very strongly that 431 00:19:30,810 --> 00:19:28,299 vaccines have something to do with some 432 00:19:32,519 --> 00:19:30,820 case of autism but it has nothing to do 433 00:19:34,590 --> 00:19:32,529 with the preservative it has to do with 434 00:19:35,700 --> 00:19:34,600 multiple vaccines simultaneously and a 435 00:19:38,190 --> 00:19:35,710 child that is immunologically 436 00:19:42,510 --> 00:19:38,200 incompetent and the consequence of that 437 00:19:44,820 --> 00:19:42,520 is can be autism just to mention one 438 00:19:46,490 --> 00:19:44,830 more thing about autism and that is kind 439 00:19:50,850 --> 00:19:46,500 of a strange case but very interesting 440 00:19:53,549 --> 00:19:50,860 there are some parents with autistic 441 00:19:55,620 --> 00:19:53,559 children who at the time of meltdown or 442 00:19:56,970 --> 00:19:55,630 some of them talk talk about meltdown 443 00:19:58,799 --> 00:19:56,980 some talk about the kids being on the 444 00:20:01,169 --> 00:19:58,809 ceiling or so forth the way they bring 445 00:20:06,570 --> 00:20:01,179 them back to semi normalcy is with the 446 00:20:07,680 --> 00:20:06,580 drop of tml yeah yeah the second part of 447 00:20:11,100 --> 00:20:07,690 your question had to do is homeopathy 448 00:20:13,409 --> 00:20:11,110 and we distinguish what we're doing from 449 00:20:15,389 --> 00:20:13,419 homeopathy according to a couple or 450 00:20:17,610 --> 00:20:15,399 three parameters one is our 451 00:20:19,510 --> 00:20:17,620 concentrations are a great deal higher 452 00:20:23,830 --> 00:20:19,520 than would be normally 453 00:20:25,510 --> 00:20:23,840 homeopathic dose we can we do go through 454 00:20:26,560 --> 00:20:25,520 FDA studies that's what these trials are 455 00:20:28,750 --> 00:20:26,570 about that I talked about in the last 456 00:20:29,860 --> 00:20:28,760 portion of the presentation in order to 457 00:20:32,170 --> 00:20:29,870 go through those trials you have to be 458 00:20:33,520 --> 00:20:32,180 able to detect the material in the vial 459 00:20:35,550 --> 00:20:33,530 which is pretty hard to do in some 460 00:20:38,140 --> 00:20:35,560 homeopathic remedies that's one change 461 00:20:40,240 --> 00:20:38,150 second change is we don't do anything 462 00:20:41,590 --> 00:20:40,250 moster cushon that doesn't do anything 463 00:20:44,380 --> 00:20:41,600 for our stuff one way or another and 464 00:20:46,990 --> 00:20:44,390 that seems to be integral to successful 465 00:20:50,290 --> 00:20:47,000 homeopathic remedy formulation third 466 00:20:54,090 --> 00:20:50,300 thing is that although you can buy 467 00:20:57,160 --> 00:20:54,100 homeopathic remedies off the shelf a 468 00:20:59,440 --> 00:20:57,170 homeopathic physician will take ten 469 00:21:02,230 --> 00:20:59,450 people with was herpes for example and 470 00:21:03,960 --> 00:21:02,240 if he sees each patient he'll send them 471 00:21:08,110 --> 00:21:03,970 home with ten different formulations 472 00:21:10,240 --> 00:21:08,120 because of their their background the 473 00:21:11,830 --> 00:21:10,250 multifactorial aspects and so forth we 474 00:21:14,050 --> 00:21:11,840 don't do that that's that's why we're 475 00:21:15,730 --> 00:21:14,060 all excited about universal doses if you 476 00:21:17,320 --> 00:21:15,740 could have one dose that treats the 477 00:21:19,600 --> 00:21:17,330 veterinary patient as well as the human 478 00:21:21,730 --> 00:21:19,610 patient that's a big deal and that again 479 00:21:23,950 --> 00:21:21,740 is a bit inconsistent with the autistic 480 00:21:31,970 --> 00:21:23,960 situation the autistic the homeopathic 481 00:21:40,370 --> 00:21:37,759 hi again a memory my question is have 482 00:21:48,340 --> 00:21:40,380 you tried the universal dose on non 483 00:21:52,390 --> 00:21:50,320 no and I'm trying to think of any that 484 00:21:58,020 --> 00:21:52,400 what's what's the non man when you're 485 00:22:03,610 --> 00:22:01,810 we're trying to treat diseases so if 486 00:22:07,180 --> 00:22:03,620 they don't have a herpes infection 487 00:22:11,440 --> 00:22:07,190 we wouldn't be treating them I I simply 488 00:22:13,030 --> 00:22:11,450 can't think of a fish flu or a there's 489 00:22:15,970 --> 00:22:13,040 certainly bird flu but the birds own 490 00:22:20,640 --> 00:22:15,980 suffer node answer your question we have